alexa Abstract | Rest as a New Transcription Factor to Control Neural Crest Development
ISSN: 2168-9431

Single Cell Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Commentary Open Access


RE1-silencing transcription factor (Rest), also known as NRSF (neuro-restrictive silencer factor), is a negative regulator of neuron-specific genes and expressed during embryonic development to prevent neural gene expression in non-neuronal cells. However, Rest null mice die by E11.5, prior to which the growth retardation caused by widespread apoptotic cell death has precluded further analyses of the potential role of Rest in vivo. In order to investigate the function of Rest in neural crest cells (NCCs) which are known to differentiate into neuronal and nonneuronal lineages, we established NCC-specific homozygous Rest conditional knockout (CKO) mice and observed their neonatal death caused by the defect of enteric nerve cells derived from NCCs. The viable heterozygous NCCspecific Rest CKO mice showed the white spotting phenotype, associated with a reduction in the number of melanoblasts, a non-neuronal derivative of NCCs, in embryonic skin. These results suggest the expression of REST during the early NCC specification stage is necessary for the proper development of NCCs. To fully understand the mechanisms of white spot formation and postnatal death or embryonic lethality mediated by the Rest ablation, future experiments should focus on single cell analysis to characterize the detailed cellular events such as reduced cell cycle, apoptosis, change of the cell fate to well explain the observed phenotypic changes.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Hitomi Aoki and Takahiro Kunisada


Rest/NRSF, Neural crest cells, Melanocytes, Conditional knockout mouse, Single Cell Analysis,Single cells,Trigeminal neuralgia

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version