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Research Article Open Access
ABSTRACT Context: Antibiotic resistance has become a global concern. There has been an increasing incidence of multiple resistances in human pathogenic microorganism in recent years, largely due to indiscriminate use of commercial antimicrobial drugs commonly employed in the treatment of infectious diseases. Flavonoids are group of naturally occurring chemical compounds, which are known to have antimicrobial properties. Aim: Present work was carried out for screening of the antimicrobial potential of flavonoids extracted from E.indica against some multidrug resistant pathogenic bacteria and fungi. Material and Methods: Different plant parts (stem, root, and leaves) of E.indica were collected and air dried and then soxhlet extracted by using standard method for flavonoids extraction. After this, extracts were tested for their antimicrobial activity using well diffusion method. Minimum inhibitory concentration and total activity were also calculated. Statistical Analysis: Mean value and Standard Deviation were calculated for the test bacteria and fungi. Data were analyzed by one way analysis of variance and P values were considered significant at P < 0.05. Results: P. aeruginosa was found to be the most susceptible organism followed by B.subtilis, S. aureus,and P.funiculosum.. A. niger was observed resistant as none of the tested extract show activity against this fungi. The range of MIC was found to be 0.019-0.625 mg/ml. Conclusion: Result of the present study reveals that extracts of E.indica are showing antimicrobial potential against tested microorganism and can be used for future antimicrobial drug.
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Author(s): Meena Agarwal, Renu Sarin