alexa Abstract | Solubility and Pre formulation Studies of Non Micronized Piroxicam SEDDS


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Abstract

Piroxicam is a poorly soluble, highly permeable drug and is characterized by a slow and gradual absorption via the oral route and this causes a delayed onset of therapeutic effect. Thus, plain piroxicam preparations are not indicated for analgesia. The results of the in vivo study revealed that the GL dosage form would be advantageous with regards to rapid onset of action, especially in various painful conditions where an acute analgesic effect is desired. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. There are several techniques to enhance the dissolution of poorly soluble drugs. Among them, the technique of liquisolid compacts is a promising technique towards such a novel aim. Hence in the present study, it was attempted to formulate Piroxicam in the form of self emulsifying drug delivery system (SEDDS) technique. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation. Compatibility study, brittleness and softness study, solubility study, phase solubility were performed. Hence it was concluded that SEDDS of Non Micronized piroxicam could be formulated. The aim of this research article is to understand and overcome the challenges of physicochemical and physical properties of liquid excipients with different type of hard capsules and to shorten expensive development phase and to reduce time to market. To facilitate the development of novel drug delivery systems, the demand for new liquid excipients have been increased. The quality of finished formulation depends not only on the active principles and production processes, but also on the performance of the liquid excipients.

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Author(s): Surya N. Singh, U. K. Patil

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