alexa Abstract | Synthesis of Some Novel 6-Nitro-8-Pyridinyl Coumarin And 6-Nitro-8-Pyranyl Coumarin Derivatives and Evaluation of Their Anti-Bacterial Activity
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article Open Access

Abstract

Two novel series of 4-methyl-6-nitro-8-(pyridin-2-yl)-2-oxo-2Hchromen- 7-yl benzoates VI-VIII and 4-methyl-6-nitro-8-(pyran-6-yl)-2-oxo-2Hchromen- 7-yl benzoates IX-XI were synthesized starting from the 8-acetyl- 4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoate V. All synthesized compounds were evaluated for their antibacterial activity using paper disc diffusion technique and agar dilution technique. Among of the tested compounds, the 8-(6-Amino-4-(2-bromophenyl)-5-thio-carbamoyl-4Hpyran- 2-yl)-4-methyl-6-nitro-2oxo-2H-chromen-7-yl benzoate Xh displayed the most promising antibacterial activity with MIC of 64, 512 and 128 μg/ ml against B. subtilis, S. aureus and E. coli, respectively

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Author(s): Radwan El-Haggar, Ola Nosseir, Riham M Shawky, Nageh Abotaleb, Tamer Nasr

Keywords

6-Nitro-8-pyridinyl-(8-pyranyl) -coumarins, Antibacterial activity., 6-Nitro-8-pyridinyl-(8-pyranyl) -coumarins, Antibacterial activity.

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