alexa Abstract | The Current State-of-the-Art in Therapeutic Genome Editing and the Future
ISSN: 2329-6682

Gene Technology
Open Access

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Research Article Open Access

Abstract

Genome editing using designer site-specific nucleases is a burgeoning field in which genomes of target cells/ organisms are now being manipulated to create/correct mutations or transcriptionally manipulate gene expression. The field began over a decade ago with zinc finger nucleases, which were soon followed by designer homing endonucleases/mega nucleases, transcription activator-like effector nucleases, and more recently, CRISPR/Cas9. Each platform has its own strengths and weaknesses but they all allow editing of the genome in cells and organisms to either study biology/function of genes or for a therapeutic effect. This review will briefly describe the various gene editing platforms and then focus in on the CRISPR/Cas9 system.

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Author(s): Donya Moradi Manesh and Punam Malik

Keywords

Mega nucleases, CRISPR/Cas9, microRNA, Gene mutations, Gene profiling, Gene Engineering

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