alexa Abstract | The Effect of Mycophenolate Mofetil on Graft Versus Host Disease in Cyclosporine Induced Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation
ISSN: 2572-4916

Journal of Bone Research
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Case Report Open Access

Abstract

Calcineurin inhibitor induced thrombotic microangiopathy (TMA) is a serious complication in hematopoietic stem cell transplantation (HSCT). Mycophenolate mofetil (MMF) is a safe immunosuppressive drug that can be used for prophylaxis of primary graft versus host disease (GVHD) after developing TMA. In this study, our two patients received CellCept® after developing cyclosporine induced TMA. Acute GVHD (skin, oral and liver) was found in both patients, nevertheless, the GVHD was not severe and can be controlled with low dose prednisolone. Therefore, MMF is an optional immunosuppressant for GVHD prophylaxis in the transplant patient diagnosed with calcineurin or m-TOR inhibitors induced TMA.

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Author(s): Niparuck P, Pukiat S, Puavilai T, Ativitavas T and Ungkanont A

Keywords

Thrombotic microangiopathy, Mycophenolate mofetil, Graft versus host disease, Hematopoietic Stem Cell Transplantation, Stem Cell Transplant, Bone Marrow Transplantation, Cancer Stem Cells (CSCs)

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