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Research Article Open Access
Background: Breast cancer (BC) is one of the most common malignancies and the leading cause of mortality in women in Ukraine. The incidence of BC in conjunction with hepatitis C virus (HCV) is increasing at a surprisingly rapid pace. The aim of the current study was to compare the mitochondrial complex between metastasis breast cancer and patients with breast cancer and hepatitis C virus.
Materials and Methods: The 147 patients with metastatic breast cancer (MBC) patients we examined. Among them 102 patients were with metastatic breast cancer (MBC), 45 patients were with metastatic breast cancer and hepatitis C virus (MBCV).
Results: The total levels of ATP and ADP in patient’s breast cancer were 1.25 ± 0.02 nmoles and 2.27 ± 0.03 nmoles in patients with breast cancer, respectively. The ratio of ATP to ADP in presented as 1.0: 1.13. In contrast, the amount of ATP and ADP secreted the patients with breast cancer and hepatitis C virus was 2.16 ± 0.4 nmoles and 3.42 ± 0.55 nmoles, respectively. The ratio of ATP to ADP, secreted from platelets upon activation, was 1: 1.59.
Conclusion: The affinity of NADH2 and NAD+ can be increased, lactate is converted to pyruvate at higher rate and lactate dependent tumor growth and proliferation can be abolished. Further investigation is needed to confirm this hypothesis. We have also identified that there is a marked difference in the amount of ADP released the patients in breast cancer. Therefore, understanding the intrinsic levels of ATP and ADP may lead to the identification of novel diagnostic method, which may assist in the early identification of patients at risk for cancer diseases. Future studies will compare ATP/ADP levels and ratios, between healthy patients and patients with cancer diseases, in order to identify any differences between their total and released amounts of ATP/ADP and the ratio between them.
ATP, ADP, Breast cancer, Metastatic breast cancer, Hepatitis C virus, Breast Cancer, Oncology, Woman Disorders