alexa Abstract | To Investigate the Impact of Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases of Cancer
[Jurnalul de Chirurgie]
ISSN: 1584-9341

Journal of Surgery
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report Open Access

Abstract

Objective: To explore the effect of laparoscopy on cancer cells and the expressions of adhesion molecules (ICAM‐1, CD44v6 & integrin β1) in peritoneal tissue and abdominal rinse in patients with colorectal carcinoma (CC). Methods: A total of 65 CC cases undergoing radical resection at our hospital were analyzed. They were divided into two groups of LAP (laparoscopy, n=35) and OP (open surgery, n=30). Peritoneal tissues were collected at incision and beyond .Also abdominal rinse was collected before tumor resection and abdomen closure. The expressions of adhesion molecules (ICAM‐1 ,CD44v6 & integrin beta 1) in peritoneal and abdominal cavities of two groups were detected by immunohistochemistry and double‐antibody sandwich ABC‐ELISA. And cancer cells in abdominal rinse were detected by peritoneal lavage cytology (PLC) for comparing two surgical methods. Results: In LAP group, PLC was positive in 3 cases (8.6%) before tumor resection and 8 cases (22.9%) before abdominal closure. In OP group, PLC was positive in 4 cases (13.3%) before tumor resection and 8 cases (26.7% ) before abdominal closure. No inter‐group difference existed in PLC (P>0.05). The expressions of CD44v6, ICAM‐1 and integrin beta 1 in abdominal cavity (before tumor resection & abdomen closure) were compared for LAP and OP groups. And there was no statistically significant difference ( P>0 05). The expressions of CD44v6 ,ICAM‐1 and integrin beta 1 in peritoneal tissues (at incision and beyond) were compared between LAP and OP groups .And there was no statistically significant difference (P>0.05) . Conclusion: Compared with CC patients undergoing traditional open surgery, the risk of exfoliated cancer cells in abdominal cavity shows no increase. And there is no impact `upon the expressions of adhesion molecules.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Xin Wang, Anren Sun, Linkang Xiao and Rong Yang

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords