alexa Abstract | Topical Binahong (Anredera cordifolia) Leaf Extract Increases Interleukin-6 and VEGF (Vascular Endothelial Growth Factor) during Burn Wound Healing in Wistar Rats Infected with Pseudomonas aeruginosa
ISSN: 0974-8369

Biology and Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Burn injuries still remain a major problem. It leads to nosocomial infection by Pseudomonas aeruginosa, the most common bacteria that infects burn injuries, due to its long duration of hospitalization. Previous research found that the extract of Anredera cordifolia, locally known as “binahong” in Indonesia, is effective in burns healing. Interleukin-6 (IL-6) and VEGF are substances that are important in healing process. This study aims to determine how topical Anredera cordifolia leaf extract accelerates burn wound healing, increases IL-6 level, and increases VEGF production in rats with Pseudomonas aeruginosa-infected burn injuries. This is an experimental study with the Posttest Only Control Group Design, involving a total of 32 samples of wistar rats with infected burn wounds. The treatment group received 2 ml of the topical extract of Anredera Cordifolia leaf while the control group received 2 ml of topical tetracycline 3%. The analysis of plasma IL-6 level was done on day 3, the VEGF analysis was done on day 5, and the observation of wound closure was done on days 3, 5, and 7. Independent t-Test was performed to obtain the mean difference of IL-6 and VEGF in control and treatment groups. The treatment group was found to have faster wound healing. Plasma IL-6 and VEGF in the treatment group was significantly higher than those in the control group (IL-6 p 5 0.001, and VEGF p 5 0.001). The application of topical Anredera cordifolia leaf extract accelerates burn wound healing, increases IL-6 level, and increases VEGF production in burns infected by Pseudomonas aeruginosa.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Dewa Made Sukrama, Desak Made Wihandani, Amertha Putra Manuaba

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords