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Research Article Open Access
In this study, the toxicological effects along with possible side effects of the classical Ayurvedic formulation Naradiya Laksmivilasa Rasa (NMB), which is used as a traditional medicine in the treatment of sinusitis in the rural population, were evaluated. During this study, various experiments on body growth rate, organ-body weight ratio, and tissue hydration indices were performed to evaluate its efficacy and toxicity. To find out the toxicological characteristics of NMB, it was administered chronically to male Sprague-Dawley rats at a dose of 100 mg/kg. After 32 days of chronic administration of the NMB preparation, the following toxicological changes were noted. Throughout the experimental period, the NMBtreated animals showed negligible [1.04% loss (p 5 0.914) to 3.18% gain (p 5 0.753)] changes in body weight and no statistically significant increase or decrease was noted. The study involving comparison of the relative weight of the major organs of the rats revealed some significant results. There was a statistically highly significant increase in the relative percentage weight of the male rat kidney, along with an increase in the absolute weight of the male rat spleen and an increase in the relative percentage weight of the male rat spleen. In the tissue hydration index experiment, there was a statistically significant increase in the water content of the male rat liver. As NMB increases abnormally, the weight of several organs increases in the body of treated rats, so it should not be administered chronically at a higher dose.
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Author(s): Shemonty Hasan, Md. Mamun Sikder, Massnoon Ali, Mustari Hossain, Tasniya Nahiyan Zulfiquar, Ferdousi Akter, Nilay Saha and M.S.K. Choudhuri