alexa Abstract | Tumoricidal Activation of Macrophages using Jatropha curcas Leaf Extract: As a Proxy for the Treatment of Cancer
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Abstract Background: Jatropha curcas (J. curcas) is a plant rich in methanolic. Macrophages can be activated to become tumoricidal through interactions with immunomodulators. The aim of this study was to investigate the effect of J. curcas leaf extracts on the phagocytic activity of macrophages. Methods: Peritoneal-derived macrophages from male BALB/c mice were obtained using the method of Colligan et al. with some modifications. Latex was added as an antigen to cultures of BALB/c mice macrophages treated with two different concentrations of J. curcas extract and the cultures were observed every 30 minutes for 2 hours. Results: Macrophage latex vacuoles were observed after treatment with 15 μg/mL J. curcas leaf extract, with a mean latex vacuole count of 7.2 vacuoles/cell and a phagocytic index (PI) of 369. Macrophage treatment with 250 μg/mL J. curcas leaf extract produced a mean latex vacuole count of 8.1 vacuoles/cell and a PI of 785. Conclusion: Treatment with J. curcas leaf extracts increased the phagocytic activity of mice macrophages.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Prayitno A, Fitria MS and Elmanda AY


Jatropha curcas, Immunomodulator, Macrophage, Tumoricidal, Jatropha curcas, Immunomodulator, Macrophage, Tumoricidal

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version