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Research Article Open Access
Background: Chronic venous insufficiency (CVI) is a frequent pathology that affects quality of life of the patients due to several symptoms such as pain, leg cramps, aching and itch. Our scope was to verify the usefulness of a supplement based on α-lipoc acid, Leucoselect® and Ginkgoselect® phytosome in patients with CVI. Methods: From July to November 2015, 30 consecutive patients with CVI received once a day a tablet containing the supplement for a period of 4 weeks. A control group of 30 subjects taking placebo and matched for CVI class, age and sex was also recruited. Clinical evaluation using VCSS and microcirculatory assessment with perimalleolar capillaroscopy were performed. A questionnaire consisting of two questions investigating presence of pain and itch/ paraesthesia was also given to the patients. Each question was scored on a dichotomous Likert scale (0=no; 1=yes). Results: A significant reduction of VCSS from baseline to 4-weeks was observed in the group of treatment respect to control group (2.70 ± 0.95 vs 0.93 ± 0.74 and 2.87 ± 0.86 vs 2.60 ± 0.81, p<0.0001). Itch and paresthesias resolved in 86.7% of patients vs 26.7% of control (p<0.0001) while leg pain improved in 70% of cases vs 23.3% of control (p<0.001). No significant changes were found between baseline and 4-weeks capillaroscopic pattern in both groups. Conclusions: After 4-weeks of treatment with α-lipoc acid, leucoselect and ginkgoselect phytosoma we observed clinical improvement of CVI symptoms, especially itch and paresthesias.
Chronic venous insufficiency, Î±-Lipoic acid, Leucoselect, Ginkgoselect, Phytosome, Atherosclerosis,Aneurysm,Angiogenesis,Angiogram