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Research Article Open Access
Objective: Relationship between Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and visceral adiposity that was assessed by ultrasonographic measurements of abdominal wall fat index (AFI) and visceral fat volume (VFV), was evaluated in our study.
Methods: A total of 150 patients (50 type 2 diabetes mellitus (DM) patients, 50 prediabetes (IFG+IGT) patients and 50 controls) were enrolled in the study. The diagnoses of type 2 DM and of prediabetes were established according to the American Diabetes Association 2010 criteria. AFI and VFV measurements were done by ultrasonography. HOMA-IR was calculated. Serum lipid profile and glucose were measured.
Results: The mean ages were 57.2 ± 9.2, 55.0 ± 11.3 and 52.8 ± 10.9 years for the type 2 DM, prediabetes and control groups, respectively. Groups were similar according to age and sex. There were significant differences between groups with respect to body mass index (BMI), waist circumference, hip circumference, and waist to hip ratio (p<0.05, p<0.05, p<0.05, and p<0.05, respectively). According to our results, there was a statistically significant positive correlation between VFV and HOMA-IR (rho=0.366, p<0.05), but no significant positive correlation between AFI and HOMA-IR (rho=0.153 and p=0.062).
Conclusion: Visceral fat volume is a better predictor for HOMA-IR than abdominal wall fat index in patients with prediabetes and type 2 diabetes mellitus.
Visceral fat volume, Abdominal wall fat index, HOMA-IR, Ultrasonography, Body Mass Index, Preventive Care, Primary Care