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Journal of Alcoholism & Drug Dependence

ISSN: 2329-6488

Journal of Alcoholism & Drug Dependence

Alcoholism and Genetics

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Alcoholism and Genetics

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Chronic use of alcohol leads to fluctuations in brain chemistry especially in the GABAergic system. Various variations occur such as changes in gene expression and down regulation of GABAA receptors. During acute alcohol withdrawal, changes also occur such as upregulation of alpha4 containing GABAA receptors and down regulation of alpha1 and alpha3 containing GABAA receptors. Neurochemical changes occurring during alcohol withdrawal can be minimized with drugs which are used for acute detoxification.

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