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Journal of Biomolecular Research & Therapeutics

ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics

Biomolecular Structures

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Biomolecular Structures

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Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a protein, DNA, or RNA molecule, and its function. The structure of these molecules is frequently decomposed into primary structure, secondary structure, tertiary structure and quaternary structure. The scaffold for this structure is provided by secondary structural elements that are hydrogen bonds within the molecule, it leads to several recognizable "domains" of protein structure and nucleic acid structure, including secondary structure like hairpin loops, bulges and internal loops for nucleic acids and alpha helices and beta sheets for proteins.

Related Journals of Biomolecular Structures
Biochemistry & Molecular Biology Journal, Biochemistry & Physiology: Open Access, Journal of Biomolecular Structure and Dynamics, Journal of Structural Biology, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,  Israel Journal of Chemistry, In Silico Techniques Explore Biomolecular Structure and Function, Annual Review of Biophysics and Biomolecular Structure.

Biomolecular Structures

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  • Albert Owusu
    Albert-Owusu-Bana-Consulting-Engineers-Australia-Rethinking-the-Application-of-Engineering-Structural-Analysis-of-Economic-Impact-Risk-Propagation-in-Infra-structures
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  • Zuheir Barsoum
    Zuheir-Barsoum-Khalifa-University-UAE-Life-extension-upgrade-and-repair-of-welded-structures-Towards-the-use-of-High-Strength-Steels
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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Werner Lottermoser
    Application of a Difference Electron Nanoscope (DEN): Correlation between 3D Magnetical Structures of Synthetic Fayalite with Synchrotron and Neutron Diffraction and Mössbauer Spectroscopy
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  • Enrique C. Samano
    An application of electron beam lithography: Location of metallic nanostructures based on DNA
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