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Clostridium Difficile Infection is also known as Clostridium enterocolitis or pseudomembranous colitis. (CDI) is a symptomatic infection due to the spore-forming bacterium, Clostridium Difficile . Main symptoms of this disease are diarrhea, fever, nausea, and abdominal pain. Clostridium difficile (C. difficile) is a bacterium that causes diarrhea and more serious intestinal conditions such as colitis.