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Journal of Drug Metabolism & Toxicology

ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology

Cytochrome 450 Drug Metabolism

Cytochrome 450 Drug Metabolism

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Cytochrome 450 Drug Metabolism

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Cytochromes P450 (CYPs) belong to the superfamily of proteins containing a heme cofactor and, therefore, are hemoproteins. CYPs use a variety of small and large molecules as substrates in enzymatic reactions. CYPs are the major enzymes involved in drug metabolism,most drugs undergo deactivation by CYPs, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYPs to form their active compounds.

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Cytochrome 450 Drug Metabolism

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