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Journal of Microbial Pathogenesis


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Cytokines is a protein secreted by the broad range of cells like immune cells, endothelial cells, fibroblasts and various stromal cells. There is significant evidence showing that certain cytokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons. Certain inflammatory cytokines are also involved in nerve-injury/inflammation-induced central sensitization, and are related to the development of contralateral hyperalgesia/allodynia.

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