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ISSN: 2469-9861

Mass Spectrometry & Purification Techniques
Open Access

Deuterium Exchange Mass Spectrometry

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Deuterium Exchange Mass Spectrometry

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Deuterium Exchange Mass Spectrometry

Deuterium exchange mass spectrometry is the mass spectrometry combined with hydrogen/deuterium. Deuterium exchange mass spectrometry is used to study the conformation and dynamics of proteins. The technique can be used in a comparative manner to identify changes in conformation and dynamics induced by ligand binding or point mutations. Deuterium exchange mass spectrometry is applicable in the areas of epitope mapping, protein-drug binding, protein-protein interactions, aggregation, effects of mutation on protein, formulations and stability testing. Hydrogen/deuterium trade mass spectrometry (H/DX-MS) is an effective device for mapping protein-protein interfaces and additionally distinguishing conformational and element annoyances in proteins. Furthermore, H/DX-MS empowers investigation of vast proteins at physiological fixations and gives understanding into the arrangement conduct of these buildings that can not be gathered from crystal structures. Hydrogen/deuterium trade mass spectrometry test used for ligand binding and the substrate identification.

Related journals of Deuterium Exchange Mass Spectrometry
Journal of Chromatography & Separation Techniques, Journal of Analytical & Bioanalytical Techniques, Journal of The American Society for Mass Spectrometry, European Journal of Mass Spectrometry, Journal of Chromatography

Deuterium Exchange Mass Spectrometry

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