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In most cases, the new lung or lungs are usually donated by a person who is under age 65 and brain-dead but is still on life-support. The donor tissue must be matched as closely as possible to recipient’s tissue type. This reduces the chances of transplant rejection. During transplantation both the lungs from the donor is transplanted into the recipient’s body.To prevent rejection, organ transplant patients must take anti-rejection (immunosuppression) drugs. These drugs suppress the body's immune response and reduce the chance of rejection.