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Enzyme Engineering

ISSN: 2329-6674

Enzyme Engineering

Enzyme Expression

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Enzyme Expression

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Relevant Topics

The metabolic enzyme expression remodeling is now widely known as hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. The highest scoring pathway is mitochondrial one-carbon metabolism and protein are markedly elevated in many cancers and correlated with poor survival in brest cancer. In this it shows the importance of mitochondrial compartmentalization of one carbon metabolism in cancer and raises important therapeutic hypotheses.

Enzymes are an important staple in the biopharmaceutical, agricultural and chemical fields. However, expression of these workhorse proteins comes with a number of problems as well. Bacterial hosts can produce large quantities of these proteins, but struggle when tasked with expression of very large proteins or proteins that require post-translational modifications. Fungal expression systems have the potential to produce toxins during the expression cycle, which can make their product unusable. Both types of hosts must undergo the extreme physiological impacts of high-level expression of the genes needed to create over-production.

Related Journals of Enzyme Expression

Bioengineering & Biomedical science JournalsBiomedical Sciences JournalsBioprocessing & Biotechniques JournalsGenetic Syndromes & Gene Therapy, Journals Proteomics, Hereditary Genetics : Current Research, Expressions Maghrebines.

Enzyme Expression

Expert PPTs

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  • Amina Dahmani
    TRANSFORMING GROWTH FACTOR-β PROGRAMS CENTRAL-MEMORY DIFFERENTIATION IN EX-VIVO STIMULATED HUMAN T CELLS BY MODULATING ID3 EXPRESSION
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  • Ildiko Molnar
    The role of tissue-specific type 2 5’-deiodinase enzyme activities in Graves’ orbitopathy and systemic sclerosis: a new candidate in thyroid autoimmunity
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  • Wail M Hassan
    Wail-M.-Hassan-University-of-Wisconsin-USA-Gene-expression-changes-triggered-by-amyloid-beta-toxicity
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  • Heidi Schalchli
    Natural products of Anthracophyllum discolor: Ligninolytic enzymes and antifungal volatile compounds
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  • C Cameron Yin
    Role of Immunoglobulin Gene Expression in Acute Myeloid Leukemia
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  • Jianbo Wang
    Transcriptome and small RNA gene expression changes in synthetic allohexaploids of
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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Joan Smith Sonneborn
    Novel anti-retroviral drug targets: Interfering siRNA and mitochondrial TERT expression
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  • Huidi Liu
    Reduced Expression of SOX7 in Ovarian Cancer: a Novel Tumor Suppressor through the Wnt/β-catenin Signaling Pathway
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  • Devathri Nanayakkara
    Context specific role of deubiquitylase enzyme, USP9X in oral squamous cell carcinoma
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  • Nasim Musa
    Role of angiotensin converting enzymes inhibitor and angiotensin receptor blockers in type 1 daibetic nephropathay
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  • Nurieva Roza Insafetdinovna
    Batf is essential for IL-4 expression in T follicular helper cells.
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  • Rivan Sidaly
    Hypoxia increases the expression of enamel proteins and cytokines in an ameloblast-derived cell line
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  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
    PPT Version | PDF Version
  • Gayatri Gogoi
    Evaluation of HR[ER/PgR] status and correlation with Ki67 expression in BC
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  • Nancy J Bigley
    Differential expression of SOCS1/SOCS3 ratios in virus-infected macrophage cell lines
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  • Lothar Brecker
    In situ NMR and STD NMR to study mechanisms of enzyme catalyzed reactions to optimize use of enzymes in organic synthesis
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  • Sungchul Ji
    Mathematical Models of RNA Expression Profiles: Potential Applications to Drug Discovery Research and Personalized Medicine
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  • Kathleen Hefferon
    Plant virus expression vectors for biopharmaceutical production
    PPT Version | PDF Version
  • P Venkataraman
    Impact of rHu-Epo supplementation on CRF induced Neurobehavioral changes in rats: Studies on correlation with APP ratio, β amyloid and pTau expression
    PPT Version | PDF Version
  • M.Krishnan
    Molecular cloning, expression, purification and functional characterization of 37 kDa Serine Protease from Bombyx mori
    PPT Version | PDF Version
  • Weiwen Zhang
    Single-cell gene expression analysis – technologies and application
    PPT Version | PDF Version
  • Ofir Menashe
    The use of constructed nano and micro-filtration membrane as a confine bioreactor for microbial growth and extracellular digestive enzymes secretion
    PPT Version | PDF Version
  • Junio Cota Silva
    Enzymes and biotechnology: Can we overcome modern challenges?
    PPT Version | PDF Version
  • John A. Barrett
    Localized regulated expression of IL-12 as a gene therapy approach to cancer immunotherapy
    PPT Version | PDF Version
  • Tony Ifeanyi Ojiezeh
    Haemogram and serum enzymes activities of Newcastle Disease Virus challenged broiler chickens following supplemental treatment with Aloe vera extract.
    PPT Version | PDF Version
  • Jackleen Raafat
    Expression of CD95 in Acute Lymphocytic Leukemia (ALL) in Egyptian Children before and after Treatment
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  • Philip J. Lucas
    Differential gene expression in the thymus to establish low toxicity chemotherapeutic agents
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  • Joanna Trojanek
    Metalloproteinases and their inhibitors gene expression profiles in leukocytes of primary hypertension (PH), non-alcoholic fatty liver disease (NAFLD), and obese children
    PPT Version | PDF Version
  • Rafael Correa-Rocha
    HIV infection of Human regulatory T cells (Treg) downregulates Foxp3 expression and produces a loss of the suppressive capacity of these cells
    PPT Version | PDF Version
  • Luminita Castillos
    Gene expression profiling for targeted cancer treatment
    PPT Version | PDF Version
  • Scott A Tenenbaum
    sxRNA: Using RNA-based, nano-switches to detect novel non-coding RNA expression
    PPT Version | PDF Version
  • Francisco J. Plou
    Transformations of carbohydrates into prebiotic oligosaccharides using free or immobilized glycosidic enzymes
    PPT Version | PDF Version
  • Juan B. Kouri Flores
    Cytokines expression during OA pathogenesis within an experimental rat model
    PPT Version | PDF Version
  • Jung-Joon Min
    Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
    | PDF Version
  • Haifei Shi
    Sex Differences in Central Expression and Anorectic Effects of Brain-Derived Neurotrophic Factor
    PPT Version | PDF Version
  • Farhad Ahmadi
    The effect of dietary zinc oxide nanoparticles on liver enzymes activity and some of blood parameters from hatch to 14 days of broiler age (1 to 14 days of age)
    PPT Version | PDF Version
  • Amparo Pascual-Ahuir Giner
    Real time analysis of gene expression in living yeast cells: Novel approach for accurate cell damage detection
    PPT Version | PDF Version
  • Marciano Viana Paes
    Expression of cytokines in tissues and correlation with histopathological changes in dengue fatal cases from Brazil
    PPT Version | PDF Version
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