Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. Hepatocellular carcinoma is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. The incidence of hepatocellular carcinoma is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of hepatocellular carcinoma.
Related Journals of Hepatocellular Carcinoma (HCC)
Clinics in Liver Disease, Digestive and Liver Disease, Clinical Liver Disease, Comparative Hepatology,Acta Hepatologica Japonica
Hepatocellular Carcinoma (HCC)
- Werner Boecker
Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: Evidence for a common origin
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- Tibor Tot
Multiparameter characterization of breast carcinoma: subgross, microscopy, proteins, and genes
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- Fathia El Sharkawi
The effect of PTEN and TRAIL genes loaded on nanoparticles on hepatocellular carcinoma
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- Yosef Yarden
Classically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3âUTR regions, although the existence of their transcribed products as independent 3âUTR RNAs is still to be confirmed. Our studies indicate that the independent 3âUTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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- Devathri Nanayakkara
Context specific role of deubiquitylase enzyme, USP9X in oral squamous cell carcinoma
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- Giselle L Gotamco
A case of hybrid carcinoma of the nose
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- Igor Malyshev
GENETIC FEATURES OF NO GENERATING SYSTEMS AND RESISTANT TO EHRLICH ASCITES CARCINOMA
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- Lubna Mushtaque Vohra
Metaplastic carcinoma of the breast and p16 positivity: What does it mean?
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- Rubens Mendes Canuto de Oliveira
Progressive Form Of Biliary And Hepatic Paracoccidioidomycosis, Simulating Cholangiocarcinoma
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- Myron R Szewczuk
Transcriptional factor Snail and MMP-9 signaling axis controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma
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- Mingsong Wu
Identification of differentially expressed genes in human lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene
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- Flavia Secco Tavares de Souza
A Comparative Study Among Elective Conventional Surgery, Urgency/Emergency Conventional Approaching and Elective Videolaparoscopic Surgery on the Treatment of Hospitalized Patients at First Surgeric Clinic of Federal Hospital of Bonsucesso with a Diagnostic of Colorectal adenocarcinoma, between January 2010 and December 2012
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- Ahmed G. Hegazi
Influence of honey in mice bearing Ehrlich carcinoma on immune status
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- Jian Jun Wei
MicroRNAs and the target genes in early tumorigenesis of fallopian/ovarian carcinoma
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