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A kidney biopsy involves taking one or more samples of kidney to look at with special microscopes. The microscopes make it possible to see the samples in greater detail. Some kidney problems can often be found with blood and urine tests, a sonogram or other special x-rays, and a physical exam rather than a biopsy. But in some individuals with certain types of kidney disease, and those with a kidney transplant that is not working well, a correct diagnosis can only be made with a kidney biopsy.