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Neuromyelitis Optica (NMO), also known as Devic's disease or Devic's syndrome. Neuromyelitis Optica (NMO) is a rare relapsing autoimmune disorder that causes inflammation in the optic nerve and spinal cord. Several factors differentiate it from MS: 1) the severity of attacks is more robust as compared to MS, 2) it does not often involve the brain, especially early in the disease, and 3) the pathophysiology differs from MS – whereas MS is thought to largely be a T-cell mediated disease, NMO is mediated by anti-aquaporin 4 antibodies. Treatment for this disease involves acute management with therapies.
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