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Preclinical Studies

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Preclinical Studies

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Preclinical trails are the processes by which test drugs and devices used are to see if they are safe and effective. In preclinical trails are drugs test first on animal bodies whether the treatment really works and also make conformation that if it is safe to test on humans. First thing for researcher is to explore, explain and describe a topic on which the research is going on and investigate how to use it to treat and prevent sickness. The researchers first get an idea for a drug target after that they develop a bioassay means a live system that can be used to measure drug effect then screening of the drug in bioassay takes place. After that establish what dosage of drug is safe and what amount of drug is toxic. Then we have to take approval from Food and Drug Administration and Investigational New Drug by making all list of applications of discovered drug.

Preclinical Studies

Expert PPTs

Speaker PPTs

  • Muhamed Fakhri Omer
    Cathodoluminescence petrography for provenance studies of the sandstones of Ora Formation (Devonian-Carboniferous), Iraqi Kurdistan Region, Northern Iraq
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  • Mustafa M Hariri
    Importance of methods’ selection in the geosciences studies and exploration
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  • Afsar Rahbar
    Studies of the importance of Cytomegalovirus infection in breast cancer
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  • Jim Polarine
    Case studies of human fl ora and spore contamination in clean rooms
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  • Gulay Yelken Demirel
    Challenges in parenteral formulation development studies and an evaluation from QbD point of view
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  • Jianfeng Hong
    Extractable and leachable studies of parenteral infusion and transfusion products
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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Arny L Blanchard
    Long-term environmental studies and stewardship in Alaska: A case study from Port Valdez
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  • Soha M Hamdy
    Biochemical studies on the effect of turmeric on breast cancer of rats
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  • Adel Nefzi
    “Adel Nefzi-Torrey-Pines-Institute-for-Molecular-Studies-USA-Diversity-Oriented-Synthesis-of-low-Molecular-Weight-Acyclic-and-Heterocyclic-Compounds-from-Resin-bound-Polyamides-Application-for-Drug-Discovery”
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  • Dalia Hussein Soliman
    “Dalia Hussein Soliman-Al-Azhar-University-Egypt-Design-synthesis-docking-and-QSAR-studies-of-novel-3-5-diaryl-pyrazole-derivatives-and-their-evaluation-as-antioxidants-and-as-Immunomodulators-inhibitors-of-TNF-α-IL-2-IL-6”
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  • Xiaomei Lu
    Ocean subsurface studies with the CALIPSO spaceborne lidar
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  • S Catherine Alexander
    Immunotoxicity of industrial effluents in fin fish: An alternative animal model for immunotoxicological studies
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  • Ferdinand N Mbagwu
    Ethnomedical studies of plants used for treatment of diseases in eastern part of Nigeria
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  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
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  • K Padmaja
    Biochemical and therapeutic studies of postpartum indigestion (ppi) in buffaloes
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  • Kishore Kadimpati
    Potential use of Sargassum cinereum biomass for removal of Lead: Kinetics, Isotherms, Thermodynamic and Characterization Studies
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  • Sharda Choudhary
    Molecular studies of Cumin (Cuminumcyminum L.), for diversity and modeling
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  • P Venkataraman
    Impact of rHu-Epo supplementation on CRF induced Neurobehavioral changes in rats: Studies on correlation with APP ratio, β amyloid and pTau expression
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  • Etakula Nagabhushan
    Studies on the Combined Effect of Multi – Walled Carbon Nano Tubes (MWCNTs) and Maleic Anhydride grafted Polypropylene (MA – g PP) on the Mechanical and Thermal Properties of Polypropylene (PP)
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  • Lynda Sharrett Field
    Preclinical studies of glucocorticoid receptor antagonists in the treatment of alcohol dependence
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  • A. E. Pillay
    Laser [213-nm] depth-profiling studies of v/ni ratios in asphaltenes following liquid nitrogen pre-treatment
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  • Nisreen E. Mahmoud
    Parasitological and comparative pathological studies on monogenean infestation of cultured sea bream (Sparus aurata, Sparidae) in Egypt.
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  • Weijia Xie
    Recent structure relationship studies (SAR) on natural occurring sulfonium salts as potent -glucosidase inhibitors
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  • Jeffrey S Patrick
    High Performance Gas Chromatography Mass Spectrometry in Addressing the Challenges of Metabolomic Studies – Separation in Time and Mass
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  • Huseyin Cimen
    Discovery-based Targeted Proteomic Studies: Gel-based and/or off-gel protein sample preparation and purification
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  • Charles F. L. Mbakaya
    Elucidating the link between environment, nutrition, host immunity, AIDS and cancer as informed by selected studies in Kenya and beyond
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  • Subir Samanta
    Design, synthesis and antidiabetic, cardiomyopathy studies of cinnamic acid-amino acid hybrid analogs
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