A prodrug design is a versatile, powerful method that can be applied to a wide range of parent drug molecules, administration routes, and formulations. Clinically, the majority of prodrugs are used with the aim of enhancing drug permeation by increasing lipophilicity, or by improving aqueous solubility. Prodrug design may improve the bioavailability of parent molecule, and thus can be integrated into the iterative process of lead optimization, rather than employing it as a post-hoc approach.
Related Journals of Prodrug design
Drug Designing: Open Access, Natural Products Chemistry & Research, Medicinal Chemistry, Research and Reviews: Journal of Pharmaceutics & Nanotechnology, International Journal of Medical and Pharmaceutical Sciences.