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Diagnosis of virus infection is usually on the basis of symptomology with no lab confirmation because: Virus infections are rarely life-threatening, limited alternatives for intervention exists. It is important in case of life testing infection, Infections for which interventions or management strategies exist, chronic infections.
In general, diagnostic tests can be grouped into 3 categories.: (1) direct detection, (2) indirect examination (virus isolation), and (3) serology.
In direct examination, the clinical specimen is examined directly for the presence of virus particles, virus antigen or viral nucleic acids. In indirect examination, the specimen into cell culture, eggs or animals in an attempt to grow the virus: this is called virus isolation. Serology actually constitute by far the bulk of the work of any virology laboratory. A serological diagnosis can be made by the detection of rising titres of antibody between acute and convalescent stages of infection, or the detection of IgM. In general, the majority of common viral infections can be diagnosed by serology. The specimen used for direction detection and virus isolation is very important. A positive result from the site of disease would be of much greater diagnostic significance than those from other sites.
Peter S. Nyasulu Prevalence and risk factors associated with acquisition of Sexually Transmitted Infections among people living with Human Immunodeficiency Virus in Diepsloot settlement, Johannesburg, South Africa PPT Version | PDF Version
S. Sarker Tracking of viral evolution during an outbreak of emerging beak and feather disease virus (BFDV) infection in the critically endangered Orange-bellied parrot (Neophema chrysogaster) PPT Version | PDF Version
Glendie Marcelin Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden in pregnant mice PPT Version | PDF Version