Figure 4: Generalized association plots (GAP) for 624 probesets of the 62 drugs with the 9 functional categories. (A) The gene expression profile map of the 624 probesets by the 62 drugs; (B) The drug-drug correlation map between the 62 drugs; and (C) The gene-gene Euclidean distance map among the 624 probesets; (D) The hierarchical clustering tree for sorting the Euclidean distance map in (C); and (E) The panel for gene selection mechanism by functional category. To the right of Figure 4A is a covariate indicating if a probeset was selected as a up-(red) or down-(green) regulated gene. In (A) and (C), the 624 probesets were sorted using the HCT-R2E in (D). In (A) and (B) permutation of the 62 drugs were divided into two layers. HCT-R2E was used for both the ordering of functions at the outer layer and ordering of drugs within each inner layer for functions.