alexa Sepsis: What We Know and What We Don't | OMICS International
ISSN: 2161-0703
Journal of Medical Microbiology & Diagnosis
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Sepsis: What We Know and What We Don't

Jyotika sharma*

Department of Microbiology and Immunology, UND School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58202-9037, USA

*Corresponding Author:
Jyotika sharma, PhD
Assistant professor
Department of Microbiology and Immunology
UND School of Medicine and Health Sciences
501 N Columbia Road, Grand Forks, ND 58202-9037, USA
Tel: 701-777-2624
Fax: 701-777-2054
E-mail: [email protected]

Received date: September 28, 2012; Accepted date: September 30, 2012; Published date: October 02, 2012

Citation: Sharma J (2012) Sepsis: What We Know and What We Don’t. J Med Microb Diagn 2:e114 doi:10.4172/2161-0703.1000e114

Copyright: © 2012 Sharma J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Medical Microbiology & Diagnosis

Abstract

 #

Sepsis is a complex immune disorder that results in 750,000 hospitalizations annually in the United States alone [1]. In addition to posing an immense health hazard with a mortality rate of 20-50%, it is also a huge economic healthcare burden with the patients consuming half of the ICU resources in the country. In October 2011, the only FDA approved drug for the treatment of sepsis (Xigris) was withdrawn from market following the much anticipated results of the clinical trial (PROWESS-SHOCK) where it failed to show any survival benefit for severe sepsis and septic shock patients [2]. As a result we are now left with no effective preventive or treatment options for this deadly immune disorder, despite three decades of active research. Why has it been so hard to tackle sepsis? One obvious reason is the complexity of this disorder as it is thought to be interplay of multiple host immune pathways [3]. The second likely reason is that most of the research has been focused on initiation of inflammatory response when the need is to take into account factors responsible for exaggeration of ongoing inflammation as well as lack of negative regulatory mechanisms/ resolution of inflammation/restoration of homeostasis.

Hyperinflammation: Role of Alarmins

Sepsis is mainly characterized by an imbalanced, hyperinflammatory response to an infection. As for any pathogenic insult, innate immune components play pivotal role in initiating the proinflammatory response required to combat infection. The key players in this process are host Pattern Recognition Receptors (PRRs) and Pathogen-Associated Molecular Patterns (PAMPs). Three families of host PRRs involved in the recognition of PAMPs are Toll-Like Receptors (TLRS), NOD-Like Receptors (NLRs) and RIG-I like Receptors (RLRs). Regardless of the origin of PAMPs or the localization of PRRs, their interaction almost always results in an inflammatory response that serves as a first line of defense against a wide variety of pathogens. On the flip side, the non-specificity of innate immune response and the antimicrobial mediators produced by the first responder cells such as neutrophils can result in severe damage to by-stander cells at the site of acute inflammation. This causes the release of endogenous host factors in the extracellular milieu. These endogenous molecules are termed alarmins, and typically perform homeostatic functions when contained within cellular compartments. However under pathological conditions, these molecules can be released either passively from dead cells or actively via non-classical secretion pathways. Once in the extracellular milieu, they exhibit immune modulatory properties such as induction of pro-inflammatory cytokines, immune cell chemotaxis and regulation of cell death [4-6].The interaction of Toll-Like Receptors (TLRs) as well as NOD-Like Receptors (NLRs) with pathogen derived PAMPs during sepsis has been studied extensively [3,7]. However, the recognition of self-molecules (alarmins) by signaling receptors and the concomitant inflammatory response is an area of research which is still in its infancy. The role of several alarmins such as High Mobility Group Box 1 (HMGB1) and S100 family of calcium binding proteins has been demonstrated in various inflammatory conditions, as well as in sepsis. However, in a complex immune disorder like sepsis which is interplay of several host immune pathways such as the coagulation system, complement cascade and even the autonomic nervous system, it is likely that several alarmins are involved at the intersections of these pathways. Thus, identification of novel alarmins and their receptors as well as downstream signaling events may aid in understanding this complex disorder and may present additional targets for effective therapeutics. Moreover, depending upon the type of infections detected in septic patients, the identification of these alarmins and alarmin receptors may present opportunities to customize the treatment options in septic patients.

Resolution of Inflammation: Return to Homeostasis

Once the pathogenic insult has been taken care of, it is imperative that the immune cells are cleared off the mileau, in order to restore the quiescent state of homeostasis. This is achieved by the process of efferocytosis, where the innate immune cells such as neutrophils, once they have completed their task of combating pathogens, start to undergo apoptosis and are eventually phagocytosed by professional phagocytes in the vicinity. Deregulation of this process can result in secondary necrosis of these apoptotic cells causing the release of host alarmins in the extracellular milieu which, we now know, play an important role in exaggeration of an ongoing inflammation. As sepsis is often characterized by massive cell death in systemic organs, it is tempting to speculate that a deregulation of efferocytosis process and turnover of neutrophils contributes to sepsis development. However, studies correlating these two processes with sepsis are surprisingly few. In addition to clearing dead cell carcasses, the process of efferocytosis also modifies the phenotype of phagocytic cells from inflammatory to anti-inflammatory nature resulting in production of host mediators such as TGF-beta and IL-10 that not only shut the inflammatory response but also inhibit further influx of immune cells [8]. All of these events constitute the complex process of resolution. How then, in the context of an inflammatory disorder such as sepsis, or for that matter any inflammatory disease condition, this regulated process of resolution is disrupted and progresses towards an accelerated and sustained condition of chronic inflammation? This is an area of investigation which may hold some key answers to queries regarding the mechanisms of sepsis development and how an otherwise beneficial host response turns to a harmful process of excessive inflammation and overt tissue destruction.

Conclusion

A lack of understanding of molecular mechanisms tipping the balance between a local, resolving inflammation to a systemic nonresolving inflammatory response has limited our efforts to find effective treatment options for sepsis. This knowledge likely holds the key to combating this deadly immune disorder.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • 10th World Congress on Alzheimers Disease & Dementia
    May 30-31, 2018 Osaka, Japan
  • 4th World Congress and Exhibition on Antibiotics and Antibiotic Resistance
    June 14-15, 2018 Barcelona, Spain
  • 4th Annual Congress on Infectious Diseases  
    September 17-18, 2018 San Diego, USA
  • 13th World Congress on Virology
    September 26-27, 2018 Montreal, Canada

Article Usage

  • Total views: 11554
  • [From(publication date):
    January-2013 - Feb 21, 2018]
  • Breakdown by view type
  • HTML page views : 7799
  • PDF downloads : 3755
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

pharma[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version