Hepatitis B: Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus. It is a major global health problem. It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.Symptoms: Most people do not experience any symptoms during the acute infection phase. However, some people have acute illness with symptoms that last several weeks, including yellowing of the skin and eyes (jaundice), dark urine, extreme fatigue, nausea, vomiting and abdominal pain.
Causes: The virus also can pass from a mother to her newborn child at birth or soon afterward. Most adults with hepatitis B get better, but a small percentage can't shake the disease and become carriers, which means they can spread it to others even when their own symptoms disappear.Diagnosis: Laboratory diagnosis of hepatitis B infection focuses on the detection of the hepatitis B surface antigen HBsAg. Acute HBV infection is characterized by the presence of HBsAg and immunoglobulin M (IgM) antibody to the core antigen, HBcAg. The presence of HBeAg indicates that the blood and body fluids of the infected individual are highly contagious.
Treatment: care is aimed at maintaining comfort and adequate nutritional balance, including replacement of fluids lost from vomiting and diarrhoea. Chronic hepatitis B infection can be treated with drugs, including oral antiviral agents.Statistics: A total of 57 cases of acute hepatitis B were reported in 2013, compared to 58 cases reported in 2012. All cases were serologically confirmed with the presence of hepatitis B surface antigen (HBsAg) and anti-HBc IgM antibody which are both associated with acute clinical presentation. The incidence rate was highest in the 25 - 44 years age group, with an overall male to female ratio of 5.2:1. Although Singapore is in an endemic region for hepatitis B infection, the hepatitis B carriage rate of 5-6% is relatively low.