Narcolepsy is a relatively rare sleep disorder it is known as an"orphan disease" this means it a disease that affects less than 5 per 10,000 people within a community. Narcolepsy is a sleep disorder which affects the brains' ability to regulate the normal sleep-wake cycle. This can lead to symptoms such as disturbed night-time sleep and excessive sleepiness throughout the day.
Emotion-induced laughter occurred in 16 patients, and of these 10 showed cataplexy for a total of 77 events (mean duration = 4.4 s). Cataplexy was marked by brief losses of mylohyoid muscle tone and by the observation of episodes of facial hypotonia, jaw drop, and ptosis. During laughter an increased hemodynamic response occurred in a bilateral network involving the motor/premotor cortex and anterior cingulate gyrus.
Severe daytime sleepiness may require treatment with high doses of stimulant medication, and sometimes a combination of stimulants may be needed. Rare or infrequent cataplexy and other associated symptoms may not require any drug treatment, or treatment on an "as needed" regimen may be adequate.