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In personality disorder, abnormalities may be seen in the frontal, temporal, and parietal lobes. These abnormalities may be caused by perinatal injury, encephalitis, trauma, or genetics. Personality disorders are also seen with diminished monoamine oxidase (MAO) and serotonin levels. However, the relationships of anatomy, receptors, and neurotransmitters to personality disorders are purely speculative at this point.
