The classical form of smallpox caused by variola has been divided into five major clinical types by world health organization (WHO):
1. Ordinary smallpox that occurs in 90% of cases with a case-fatality rate ranging from 10â75% correlated with the severity of rash.
2. Modified smallpox, that occurs in 5% of cases with a case-fatality rate near 10%, less severe in its clinical presentation and frequent among previously vaccinated individuals;
3. Flat smallpox, that occurs in 5% of cases with a case-fatality rate above 80%, distinguished by a more slowly developing rash and generalized infection;
4. Haemorrhagic smallpox, that occurs in 1% of cases with casefatality rate of 100%, characterized by haemorrhages into the skin and mucous membranes;
5. Variola sine eruption, that presents as a fever without rash; thus, serological evidence is required to confirm VARV infection.
(Smallpox: New Perspectives Regarding Risk Assessment & Management- Jan-Cedric Hansen)
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Last date updated on January, 2021