alexa Amebiasis | Spain | PDF | PPT| Case Reports | Symptoms | Treatment

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Amebiasis

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  • Amebiasis

    Disease Treatment: For symptomatic intestinal infection and extraintestinal disease, treatment with metronidazole or tinidazole should be followed by treatment with iodoquinol or paromomycin. Asymptomatic patients infected with E. histolytica should also be treated with iodoquinol or paromomycin, because they can infect others and because 4%–10% develop disease within a year if left untreated. Asymptomatic carriers of E. histolytica should be treated with a luminal agent to minimise the spread of disease and the risk of developing invasive disease.In patients with invasive disease, metronidazole should be used in conjunction with a luminal agent to eradicate the organism. The role of surgery is generally limited to patients with complications of invasive disease. Surgical drainage is generally unnecessary in amoebic liver abscess, as cure can be achieved with medical therapy alone. Major Research on Disease: Most patients have a gradual illness onset days or weeks after infection. Symptoms include cramps, watery or bloody diarrhea, and weight loss and may last several weeks. Occasionally, the parasite may spread to other organs (extraintestinal amebiasis), most commonly the liver. Amebic liver abscesses may be asymptomatic, but most patients present with fever and right upper quadrant abdominal pain, usually in the absence of diarrhea. Asymptomatic carriers of E. histolytica should be treated with a luminal agent to minimise the spread of disease and the risk of developing invasive disease. The role of surgery is generally limited to patients with complications of invasive disease. Surgical drainage is generally unnecessary in amoebic liver abscess, as cure can be achieved with medical therapy alone. The role of radiologically guided percutaneous therapeutic aspiration in uncomplicated amoebic liver abscess is controversial but it has been shown to be of some clinical benefit in patients with large abscesses. Aspiration should be considered in patients with an uncertain diagnosis, lack of response to medical therapy (persistent fever > 4 days), and large abscesses at risk of rupturing (especially left lobe abscesses, as these may rupture into the pericardial space)

 

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