Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest and can lead to a variety of emotional and physical problems. Symptoms of depression are Feelings of sadness, emptiness, angry outbursts, Sleep disturbances, Changes in appetite, Anxiety, Trouble thinking, making decisions etc.
In Spain, according to a study in the community, weighted prevalence was estimated at 6.19%, with differences between the sexes (4.5% in males and 7.8% in females). Likewise, it was estimated that 20% of patients in primary care may present a depressive disorder.
To diagnosis Depression various tests like Physical test, Lab tests, Psychological test, Diagnostic and Statistical Manual of Mental Disorders (DSM-5) can be conducted. Medications and psychological counseling (psychotherapy) are very effective for most people with depression. Selective serotonin reuptake inhibitors (SSRIs), Serotonin-norepinephrine reuptake inhibitors (SNRIs), Norepinephrine-dopamine reuptake inhibitors (NDRIs), Atypical antidepressants etc. antidepressant drugs can be used.
Many scientists in Spain working on the strategy of combining antidepressants in the treatment of major depression: clinical experience in Spanish outpatients.