Diabetes insipidus is an uncommon disorder characterized by intense thirst, despite the drinking of fluids (polydipsia), and the excretion of large amounts of urine (polyuria).Diabetes insipidus is caused by abnormality in the functioning or levels of antidiuretic hormone (ADH), also known of as vasopressin.It is manufactured in the hypothalamus and stored in the pituitary gland, ADH helps to regulate the amount of fluid in the body. ADH is released from the pituitary gland which prevents the excretion of fluids from the body in the form of urine. There are four types of diabetes insipidus Central diabetis insipidus or Cranial Diabetis insipidus and Nephrogenic diabetes insipidus
Treatment mainly aim to reduce to reduce the amount of urine your body produces. Mild cranial diabetes insipidus may not require any medical treatment, the only think to do is to increase the amount of water consumption. Central diabetes insipidus may be controlled with desmopressin,it is a synthetic analogue of antidiuretic hormone (ADH). Desmopressin is available either an injection, a nasal spray, or tablets Generally, it can be administered 2-3 times per day. Patients may require hospitalization to establish fluid needs. Frequent electrolyte monitoring is recommended during the initial phase of treatment. Nephrogenic DI is treated with anti-inflammatory medicines and diuretics.
The extrapolated incidence in Spain is 6,042. The population estimated used is 40,280,780.
1)Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study