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Legionnaires Disease

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  • Legionnaires Disease

    Pathophysiology: Legionnaires’ disease is a serious lung infection caused by Legionella bacteria. Legionnaires' disease, also known as legionellosis or Legion fever. Over 90% of cases of Legionnaires'disease are caused by Legionella pneumophila. These bacterial species can be water-borne or present in soil, whereas L. pneumophila has only been found in aquatic systems, where it is symbiotically present in aquatic-borne amoebae. It thrives in temperatures between 25 and 45 °C (77 and 113 °F), with an optimum temperature of 35 °C (95 °F).

  • Legionnaires Disease

    Treatment: People of any age may suffer from Legionnaires' disease, but the illness most often affects middle-aged and older persons, particularly those who smoke cigarettes or have chronic lung disease. Immunocompromised people are also at higher risk. Pontiac fever most commonly occurs in persons who are otherwise healthy. A significant under-reporting problem occurs with legionellosis. Even in countries with effective health services and readily available diagnostic testing, about 90 percent of cases of Legionnaires' disease are missed.

  • Legionnaires Disease

    The study included the 6 LCPD cases and 39 matched controls. The median number of controls per case was 6.5 (range: 4–9). Medication history was available for all patients, either from site records (41 children) and/or from concomitant medication forms from past PACTG clinical trials that the children had been enrolled in (4 children). Complete treatment histories from the time of birth were available for 34 of the 45 children for antiretroviral treatment and 22 for corticosteroid treatment. Before the LCPD diagnosis date for the LCPD cases (index cases), 67% of cases.

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