The most common type of lip cancer begins in the squamous cells, the thin, flat cells that line the lips and mouth. Lip cancer symptoms are very similar to those of other types of oral cancer. It can often be mistaken for a cold that won’t go away, or a persistent toothache. Other symptoms and signs include, A sore in the mouth that does not heal, Persistent mouth pain, A lump or thickening in the cheek, A white or red patch on the gums, tongue, tonsil, or lining of the mouth, A sore throat or feeling that something is caught in the throat that does not go away.
The incidence of lip cancer in Granada, Spain, is much higher than that recorded in other countries. In order to determine the risk factors for metastases, a retrospective hospital-based study was conducted of 251 cases of lower lip cancer diagnosed and treated during a 10-year period from 1985 to 1995. All patients studied had a minimum follow-up of five years. Among the metastasis risk factors considered, only localization in commissure showed statistical significance (p < 0.001).