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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy,
     a major cause of the nephrotic syndrome in adults, is characterized by the presence of glomerular deposits that typically contain immunoglobulin and complement components. Membranous nephropathy (MN) is among the most common causes of the nephrotic syndrome in nondiabetic adults, accounting for up to one-third of biopsy diagnoses in some regions. 

  • Membranous nephropathy

    Disease pathophysiology: 

    Among IgG subtypes, non-complement-fixing IgG4 complexes that contain diverse antigens might have a major role because these complexes cannot be eliminated by complement-mediated pathways. Binding of circulating antibodies to antigens that may be endogenous constituents of the podocyte membrane. 

  • Membranous nephropathy

    Disease statistics:

    The percentage of diseases in the present study was 65.8 (2,154 from a total of 3,275 glomerular diseases). The five most common glomerular diseases were IgM nephropathy (986 cases, 45.8%) followed by IgA nephropathy (386 cases, 17.9%), membranous nephropathy (341 cases, 15.8%), diffuse endocapillary proliferative glomerulonephritis (GN) (114 cases, 5.3%) and diffuse crescentic GN (71 cases, 3.3%) respectively.

  • Membranous nephropathy

    Disease treatment:

    "Membranous nephropathy is an immune-medicated disorder. Immune system is a protective system of the body and it can prevent against the invaders of outside pathologic substances.  The inflammation can cause the thickening of glomerular basement membrane. The glomerular basement membrane is the part of the kidneys that helps filter waste and extra fluid from the blood. 

  • Membranous nephropathy

    Major research on disease: 

    2 year study of efficacy and safety of intravenous belimumab versus placebo in subjects with idiopathic membranous nephropathy. In membranous nephropathy, immune system fails to function properly and attacks glomeruli by mistakes, thus resulting in inflammation in kidneys.

Expert PPTs

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  • Hayam I Gad
    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
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