a major cause of the in adults, is characterized by the presence of glomerular deposits that typically contain immunoglobulin and complement components. Membranous nephropathy (MN) is among the most common causes of the nephrotic syndrome in nondiabetic adults, accounting for up to one-third of biopsy diagnoses in some regions.
The percentage of diseases in the present study was 65.8 (2,154 from a total of 3,275 glomerular diseases). The five most common glomerular diseases were IgM nephropathy (986 cases, 45.8%) followed by IgA nephropathy (386 cases, 17.9%), membranous nephropathy (341 cases, 15.8%), diffuse endocapillary proliferative glomerulonephritis (GN) (114 cases, 5.3%) and diffuse crescentic GN (71 cases, 3.3%) respectively.
" is an immune-medicated disorder. Immune system is a protective system of the body and it can prevent against the invaders of outside pathologic substances. The inflammation can cause the thickening of glomerular basement membrane. The glomerular basement membrane is the part of the kidneys that helps filter waste and extra fluid from the blood.
2 year study of efficacy and safety of intravenous belimumab versus placebo in subjects with idiopathic mn membranous nephropathy, immune system fails to function properly and attacks glomeruli by mistakes, thus resulting in inflammation in kidneys.