Mouth cancer may arise as a primary lesion originating in any of the tissues in the mouth, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity. Most cases of mouth cancer are linked to tobacco and alcohol. Cigarette, cigar and pipe smoking are the main forms of tobacco use in the UK.
However, the traditional ethnic habits of chewing tobacco, betel quid, gutkha and paan are particularly dangerous. Many recent reports have linked mouth cancer to the human papillomavirus (HPV). HPV is the major cause of cervical cancer and affects the skin that lines the moist areas of the body. According to World Health Rankings Spain have 3.34 death rates per 10,000 people.