Non-melanoma skin cancer is a malignant tumor that starts in cells of the skin. Malignant means that it can spread, or metastasize, to other parts of the body. The two most common types of non-melanoma skin cancer are basal cell carcinoma and squamous cell carcinoma. During the period 1981–2012, age-standardised incidence rates for all cancers rose from the beginning of the period and started to decline from 2000 onwards among men, and increased across the whole period among women. Differences in incidence trends between men and women might be attributable to the gender-specific case-mix of sites for all cancers, and to differences in risk factors specific to certain cancer sites in men and women, with smoking being the main factor accounting for these differences between the sexes.
For some patients, a clinical trial is the best treatment option available. Because standard treatments are not perfect, patients are often willing to face the added uncertainty of a clinical trial in the hope of a better result. Even if they do not benefit directly from the clinical trial, their participation may benefit future patients with skin cancer. The main treatment options are: Mohs micrographic surgery, Excision,Radiation therapy, Curettage and electrosurgery, Cryosurgery.