Non-ulcer dyspepsia (NUD) is a common problem wherein patients suffer from indigestion and other symptoms suggestive of an ulcer, but no abnormality is found on investigation. A lower prevalence of 23.9% is seen in Spain.
Treatment with medications has variable success. Some patients obtain relief from antacids or acid-suppressing drugs, and some patients with symptoms suggestive of a problem with stomach emptying may be helped by medications which increase emptying. Prokinetic agents would empirically seem to work well since delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia.