Pathophysiology: A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue.
Symptoms: In their early stages, soft-tissue sarcomas usually do not cause symptoms. Because soft tissue is relatively elastic, tumors can grow rather large, pushing aside normal tissue, before they are felt or cause any problems. The first noticeable symptom is usually a painless lump or swelling. As the tumor grows, it may cause other symptoms, such as pain or soreness, as it presses against nearby nerves and muscles.
Treatment: The stage of the sarcoma is based on the size and grade of the tumor, and whether the cancer has spread to the lymph nodes or other parts of the body (metastasized). Treatment options for soft-tissue sarcomas include surgery, radiation therapy, and chemotherapy. Surgery is the most common treatment for soft-tissue sarcomas. It is important to obtain a margin free of tumor to decrease the likelihood of local recurrence and give the best chance for eradication of the tumor.
Statistics: The soft-tissue sarcomas are a group of rare but anatomically and histologically diverse neoplasms. This is due to the ubiquitous location of the soft tissues and the nearly three dozen recognized histologic subtypes of soft-tissue sarcomas. In the United States, 7,800 new cases of soft-tissue sarcoma are identified annually, and 4,400 patients die of the disease each year. The age-adjusted incidence is 2 cases per 100,000 persons. Gender There is a slight male predominance, with a male to female ratio of 1.1:1.0. Age The age distribution in adult soft-tissue sarcoma studies is: < 40 years, 20.7% of patients; 40-60 years, 27.6% of patients; > 60 years, 51.8% of patients.