A P Manjikyan
Yerevan State Medical University, Armenia
A P Manjikyan has graduated as Pharmacist in 2008 from Yerevan State Medical University. She is working in the Department of Pharmacy and doing PhD research under the supervision of Professor M G Balasanyan at YSMU, Armenia. Her research focuses on natural compounds anti-inflammatory and anti-nociceptive activities.
Satureja hortensis L. plant’s (Lamiaceae) pharmacological activities appears in a wide spectrum, due to their secondary metabolites and essential oils. The antimicrobial, antinociceptive and anti-inflammatory activities of Armenian flora Satureja hortensis L. leaves essential oil have been studied. The mentioned oil antinociceptive and anti-inflammatory activities have been estimated correspondingly in the tail-flick and xylene induced acute ears edema test of rats’ experimental model. The rats were pretreated with 20, 50 and 100 mg/kg doses. Essential oil antimicrobial effects preliminary qualitative comparable estimation was studied in a number of conditionally pathogenic microorganisms. The experiments were carried out in vitro in the petri plates using Mueller-Hinton media. The obtained results showed that the highest antinociceptive activity of the mentioned oil registered in the dose 50 mg/kg for 62.95% (p<0,001) and the anti-inflammatory activity is highly expressed in the dose 20 mg/kg, preventing edema for 50.45% (p<0.05). It was revealed that the essential oil has certain activity on E. coli, S. aureus, Bacillus sp., and fungi of Candida type. These results indicated that Satureja hortensis L. leaves essential oil could serve as a potential source for development of new agents with analgesic, anti-inflammatory and antimicrobial activities.