Abdulkader Rahmo has completed his Diploma in Biochemistry in 1988 at the Swiss Federal Institute of Technology (ETHZ), his Ph.D. in Biochemistry and Molecular biology in 1994 at the University of Southern California (USC) in Los Angeles USA. He is currently heading the medical biotech section at the National Commission for Biotechnology. He is sole author of several scientific books and coauthor of many scientific articles.
We have recently introduced a novel human adult stem cell type: Small, Mobile Stem cells (SMS cells), exhibiting exceptional characteristics conducive to morphogenesis in standard media conditions. We have outlined and defined details of several complex new processes, in a simple parametrically “poor” set up. In vitro and de novo established macro structures demonstrate high regenerative potency. Th e observed structures appear to be highly relevant to multiple tissues of in vivo model systems. Observed complex in vitro constructive activity is mediated by unit assemblies of cooperating cells which we designate as Multi-cellular Micro Machines (M3). M3 are built by cells derived from cultured SMS cells. They emanate reproducibly in vitro and can be phenotypically categorized according to constructive activity. M3 are not artificial constructs of the in vitro SMS cell system, but are representative of recurring components of diverse native tissues. Th e choreographic self organization of SMS cells and their derivatives into various functional multicellular (M3) units is suggestive of autoinduced and autopoietic processes typical of organ genesis. Exploring these tissue constructive actors would usher a new era in tissue engineering, and enhance prospects for autologous tissue transfer.