Southern University of Chile, Chile
The Ph.D Alejandro Yañez is Full Professor at Universidad Austral de Chile with postdoctoral visits at theUniversity of Missouri Kansas City USA and IRB, Barcelona, Spain. At present the Ph.D Yañez is the Director of mention of Ph.D program of Cell and Molecular Biology of Universidad Austral de Chile and director and founder of AUSTRAL Omics, the first center of biotechnology of the south of Chile. The Ph.D Yañez is one of the main referent in the study of fish pathogenic bacteria, Piscirkickettsia salmonis, being part and director of several projects in this area, also is member of interdisciplinary center of aquaculture research (INCAR).
Piscirickettsia salmonis is a Gram-negative intracellular bacterial pathogen isolated from infected farmed salmonids in where cause the salmonidpiscirickettsialsepticaemia (SPS). P. salmonisis member of the classGammaproteobacteria, classified within order Thiotrichales close to Francisella and Legionella genus. Here, we present the genome sequence analysis of pathogenic strain of P. salmonis AUS 005, in order to understand its genomic features and its pathogenic role. The P. salmonis genome consist in a single circular chromosome of 3,4Mp with 1400 Kb in size more in comparation to Francisellanoatunensis sub sp. Orientalis strain Toba04. The GC content was 37.37%. The annotation resulted in a total of 2,571 protein-coding gene predictions, with 1,873 well-annotated genes in which were identified a variety of genes associated in pathogenicity, environmental adaptation, metabolic pathways and iron acquisition, as well as transposable elements and insertion sequences (ISs). The metabolic pathways prediction indicates the absence of biosynthetic and catabolic pathways of cysteine and the complete pathways of TCA cycle. Surprisingly, the genome of this immobile bacterium revealed several genes encoding components of flagellum. The availability of the P. salmonis genome represents a biotechnological opportunity for understand the molecular mechanisms of pathogenecity and the development of new therapies to counteract the piscirickettsiosis.