Wake Forest School of Medicine, USA
Aleksander Skardal received his Ph.D. at the University of Utah where he his research focused on hydrogel biomaterials and biofabrication techniques for engineering 3-D tissue constructs. He is currently at the Wake Forest Institute for Regenerative Medic ine performing research in the areas of perinatal stem cell applications and the development of 3-D tissue models for in vitro biological exploration and drug screening.
Cancer treatments have advanced in recent years, yet current models for drug discover y and metastasis exploration poorly mimic human cancer in vivo. Research generally relies on a nimal systems and two-dimensional (2-D) cultures, both of which suffer from inadequacies. Alternatively, 3-D systems of human-derived cells can promote cell-cell and cell-matrix interactions, resembling in vivo conditions, but unfortunately are largely underu tilized for cancer research. Here we present multiple host tissue-tumor systems for in vitro modeling of colon carcinoma metastasis with implications in exploring cancer biology and the potential to streamline the drug development pipeline.