Ali Gamal Alkaf is a professor in Sana University, Yemen


Overview & Objectives: Acute renal failure (ARF) is characterized by a rapid, potentially reversible, decline in renal function including rapid fall in glomerular filtration rate (GFR) and retention of nitrogenous waste products over a period of hours or days. Shilajit is an herb-mineral drug, which oozes out from a special type of mountain rocks in the peak summer months. It is found at high altitudes ranging from 1000 to 5000 meters (Yemen & Himalaya). The active constituents of shilajit consists of fulvic, humic and amino acids, dibenzo-alpha-pyrons and related metabolites, small peptides (constituting non-protein amino acids), and some lipids. Animals & Methods: Yemeni shilajit's sample was collected and purified. 18 Rabbits were divided into 3 groups equally. Group (A) rabbits were injected by glycerol-induced acute renal failure , while Group (B) were injected by glycerol-induced ARF after the treatment with Dhamar shilajit, (C) rabbits were given only distilled water and served as a standard. All of the 3 groups were sacrificed with an overdose of ether anesthesia after overnight fasting. Blood was drawn from the ear vein for serum separation and freezing at –20ºC till time of the kidney function test (SC and BUN). Results: Data of the present study showed that the Dhamar Yemeni-shilajit used in present study have no effect on treatment of acute renal failure but it can play a role as a preventive method for glycerol-induce ARF by maintaining the kidney function tests, serum creatinine and blood urea nitrogen in the normal range. Conclusion: While shilajit sample used in present study has no effect on treatment of ARF, it can play a role as a protective method.