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Biography

"Ana Beatriz Gorini da Veiga completed her Ph.D. in 2005 and was awarded the National Scientist of the Year in Brazil. She is Associate Professor at UFCSPA since 2006, with research projects on molecular epidemiology of human pathogenic viruses to understand how changes in viral genomes contribute for infection and disease progression. She is the coordinator of Center for Technology Innovation, managing Intellectual Property and Technology Transfer Policies at the University. At the moment she has 2 Pos-doc fellows, 3 Master students, 3 Doctorate Students and 3 undergraduate students working in research projects on pathogenic viruses with her at the laboratory."

Abstract

"During the 2009 Influenza A pH1N1 pandemics in Brazil, the most affected state was Rio Grande do Sul (RS), with over 3,000 confirmed cases, including 298 deaths. While no cases were confirmed in 2010, 103 infections with 14 deaths by pH1N1 were reported in 2011. Genomic analyses of the circulating viruses are fundamental to understand viral evolution and to support vaccine development against these pathogens. This study investigated whole genomes of six pH1N1 virus isolates from pandemic and postpandemic periods in RS, Brazil. Phylogenetic analyses using the concatenated genome segments demonstrated that at least two lineages of the virus co-circulated in RS during the 2009 pandemic period. Moreover, our analysis showed that the postpandemic pH1N1 virus from 2011 composes a distinct clade, whose ancestor belongs to clade 7. All six isolates presented amino acid substitutions in their proteins in relation to those from the archetype strains California/04/2009 and California/07/2009. The 2011 isolates present more amino acid substitutions and most of their genes were under purifying selection. Based on the amino acid substitutions in HA epitopes, the predicted vaccine efficacy against the 2011 isolates was 31.44% (dominant epitope D), while against the pandemic isolates was 39.84% (dominant epitope E)."

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