Tehran University of Medical Sciences, Iran
Araz Sabzvari graduated from Tabriz pharmacy faculty with Pharm D. degree in 2006. He has been a Pharmaceutics PhD student in Tehran University of medical science, faculty of pharmacy since 2006. He has three publications (as arazsabzevari). he was a managing director of Did GostarTeb Co.(2008- 2009) board member of Did GostarTeb Co.(2008-2010) Managing director and vice chairman of Did GostarDarou (2009 -2010) vice chairman of Nano FanavaraneDarouAlvand Co. (2011- up to now)
The purpose of this project was to prepare triamcinolone acetonide (TA) nanoparticles (NPs) using poly (d,l-lactide-co-glycolide) (PLGA) (negative surface charge) and Poly( -amino ester)(PBAE) (positive surface charge) polymers, and evaluate their physicochemical characteristics for use as a topical nanosuspensionin ocular drug delivery. This is based on the background that applyingtopical nanosuspension of a drugmay improve its effectiveness in the treatment and prevention of uveitis and eliminate the side effects associated with its ocular injection as well. Polymeric NPs of TA were prepared using the modified emulsification/solvent diffusion methodfollowed by successive filtration through 3, 2, and 0.8μm filters to eliminate the non-encapsulated TA crystals. Factors related to preparation (type of stabilizer, homogenization method, the drug/polymer ratio and solvent elimination method) were studied in terms of their effect on NPs size as well as drug loading efficiency. Physicochemical studies includingmucoadhesivenessstudy, Scanning electron microscopy(SEM),Differential scanning calorimetry(DSC),Fourier transform infrared spectrometry(FT-IR), X-raydiffraction, and in vitro TA release on PLGA-TA- NPs (ζ potential:-6.8 mV) and PBAE-TA-NPs (ζ potential:+17 mV). NPs of appropriate size (180-195nm)with a smooth surface, controlled release profile and noticeablemucoadhesiveness properties were resulted andthe drug was dispersed and loaded well within the polymers (3%-5.5%). Accordingly, the prepared NPs seem to be suitablealternative for use in ocular drug delivery with the aim oftreatment and control of uveitis.